Jan 15, 2014 · Significance: Autophagy is a highly conserved eukaryotic cellular recycling process. Through the degradation of cytoplasmic organelles, proteins, and macromolecules, and the recycling of the breakdown products, autophagy plays important roles in cell survival and maintenance. Autophagy. 3(6):553-60. Klionsky DJ, Abdelmohsen K, Abe A et al. 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1):1-222 [PMID 26799652] Martinez-Lopez N, Athonvarangkul D, Mishall P et al. Autophagy proteins regulate ERK phosphorylation. Nat Commun. 4:2799. Mizushima N, Yoshimori ... Autophagy down-regulates the Wnt signal transduction pathway via targeted degradation of a key signaling protein. This may provide an explanation for autophagy's role in tumor suppression.
Autophagy is a transport system mediated by vesicles, ubiquitous in eukaryotic cells, by which bulk cytoplasm is targeted to a lysosome or vacuole for degradation. In the yeast Saccharomyces cerevisiae , autophagy is triggered by nutritional stress conditions (e.g., carbon- or nitrogen-depleted medium). In this study we showed that there is induction of autophagy in second-fermentation yeasts ... Autophagy is a highly conserved pathway (from yeast to human) of cellular “self-eating” that is essential for metabolism and survival during stress conditions. Basal autophagy is low, but is upregulated during stress conditions such as nutrient deprivation and pathogen infection. In 2005, Daniel J Klionsky launched Autophagy, a scientific journal dedicated to this field. The first Keystone Symposia Conference on autophagy was held in 2007 at Monterey. In 2008, Carol A Mercer created a BHMT fusion protein (GST-BHMT), which showed starvation-induced site-specific fragmentation in cell lines.
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various ... Autophagy is een internationaal, aan collegiale toetsing onderworpen wetenschappelijk tijdschrift op het gebied van de celbiologie.Het wordt uitgegeven door Landes Bioscience en verschijnt 8 keer per jaar. Klionsky was elected as a Fellow of the American Association for the Advancement of Science (AAAS) in 2009 and is currently the Alexander G. Ruthven Professor of Life Sciences. Field(s) of Study Molecular and Cell Biology, Protein Targeting, Organelle Biogenesis, Autophagy
Apr 27, 2010 · D. J. Klionsky, Autophagy fights disease through cellular self-digestion. Nature 451, 1069 – 1075 (2008). Eukaryotic cells have evolved strategies to respond to stress conditions. For example, autophagy in yeast is primarily a response to the stress of nutrient limitation. Autophagy is a catabolic process for the degradation and recycling of cytosolic, long lived, or aggregated proteins and excess or defective organelles. In this study, we demonstrate a new pathway for the induction of autophagy ...